Makoto Goto Selected Research

Werner Syndrome (Werner's Syndrome)

1/2019	Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome.
11/2018	Aging-associated latent herpes viral infection in normal Japanese individuals and patients with Werner syndrome.
5/2016	Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome.
11/2015	Multiplex cytokine analysis of Werner syndrome.
3/2015	WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.
12/2014	First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygous LMNA mutation.
12/2012	Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome.
12/2008	Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
8/2008	Syndrome-causing mutations in Werner syndrome.
7/2008	Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein.

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Makoto Goto Research Topics

Disease

18	Werner Syndrome (Werner's Syndrome) 01/2019 - 03/2003
5	Rheumatoid Arthritis 03/2012 - 01/2002
4	Diabetes Mellitus 05/2016 - 03/2003
4	Inflammation (Inflammations) 05/2016 - 06/2008
3	Carcinogenesis 07/2011 - 02/2003
2	Skin Ulcer 05/2016 - 11/2015
2	Aneuploidy (Aneuploid) 07/2004 - 11/2003
1	Drug-Related Side Effects and Adverse Reactions 01/2022
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019
1	Pancreatitis 01/2019
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019
1	Virus Diseases (Viral Diseases) 11/2018
1	Abdominal Obesity 11/2015
1	Dyslipidemias (Dyslipidemia) 06/2010
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2008
1	Neoplasms (Cancer) 05/2008
1	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2007
1	Chromosomal Instability (Chromosome Stability) 05/2007
1	Systemic Scleroderma (Systemic Sclerosis) 01/2006
1	Sclerosis 01/2006
1	Abdominal Pain (Pain, Abdominal) 08/2002
1	Rheumatic Diseases (Rheumatism) 08/2002
1	Hemorrhage 08/2002
1	Peptic Ulcer (Peptic Ulcers) 08/2002
1	Vasculitis (Vasculitides) 08/2002
1	Autoimmune Diseases (Autoimmune Disease) 01/2002

Drug/Important Bio-Agent (IBA)

4	C-Reactive ProteinIBA 11/2018 - 12/2012
4	Immunoglobulin G (IgG)IBA 11/2018 - 01/2002
4	DNA (Deoxyribonucleic Acid)IBA 08/2008 - 03/2003
2	Pharmaceutical PreparationsIBA 01/2022 - 08/2002
2	AntibodiesIBA 11/2018 - 01/2006
2	Proteins (Proteins, Gene)FDA Link 03/2015 - 07/2008
2	AA amyloidosisIBA 03/2012 - 09/2011
2	Telomerase (Telomerase Reverse Transcriptase)IBA 07/2011 - 07/2004
2	SirtuinsIBA 12/2008 - 07/2008
2	RNA Helicases (RNA Helicase)IBA 08/2008 - 06/2008
2	OligosaccharidesIBA 06/2007 - 01/2002
1	Methylprednisolone FDA LinkGeneric 01/2019
1	Prednisolone (Predate)FDA LinkGeneric 01/2019
1	GlucocorticoidsIBA 01/2019
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2018
1	Biomarkers (Surrogate Marker)IBA 05/2016
1	CytokinesIBA 11/2015
1	ChemokinesIBA 11/2015
1	Lamin Type A (Lamin A)IBA 12/2014
1	Nuclear Proteins (Protein, Nuclear)IBA 12/2014
1	Amyloid (Amyloid Fibrils)IBA 09/2011
1	Fenofibrate (CiL)FDA LinkGeneric 06/2010
1	5,6-dihydroxy-2-dimethylaminotetralin (M 7)IBA 06/2010
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2010
1	p38 Mitogen-Activated Protein KinasesIBA 12/2008
1	Fas Ligand Protein (Fas Ligand)IBA 06/2008
1	LigandsIBA 06/2008
1	CamptothecinIBA 05/2008
1	Exonucleases (3' 5' Exonuclease)IBA 05/2008
1	MutagensIBA 05/2008
1	A-Form DNA (A-DNA)IBA 05/2008
1	RNA (Ribonucleic Acid)IBA 01/2006
1	DNA HelicasesIBA 01/2006
1	EnzymesIBA 01/2006
1	AutoantibodiesIBA 01/2006
1	ImmunosorbentsIBA 01/2006
1	Pioglitazone (Actos)FDA Link 10/2004
1	AgarIBA 11/2003
1	Indicators and Reagents (Reagents)IBA 08/2003
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 08/2003
1	Mitochondrial DNA (mtDNA)IBA 03/2003
1	Biological ProductsIBA 02/2003
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 08/2002
1	Immunosuppressive Agents (Immunosuppressants)IBA 08/2002
1	Misoprostol (Cytotec)FDA LinkGeneric 08/2002
1	Adrenal Cortex Hormones (Corticosteroids)IBA 08/2002
1	Analgesics (Analgesic Drugs)IBA 08/2002
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2002
1	Proton Pump InhibitorsIBA 08/2002

Therapy/Procedure

1	Transplantation 01/2019
1	Caloric Restriction 12/2008
1	Therapeutics 08/2002
1	Gastrointestinal Endoscopes 08/2002